Research findings from Catholic University, Institute of General Pathology update understanding of central nervous system disease vaccines

New research, 'Administration of PLP139-151 primes T cells distinct from those spontaneously responsive in vitro to this antigen,' is the subject of a report. "We examined the TCR repertoire used by naive SJL mice in their in vitro spontaneous response to proteolipid protein (PLP) 139-151 by Vbeta-Jbeta spectratyping and compared it to that used after immunization with the peptide. T cells from immunized mice use the public rearrangement Vbeta10-Jbeta1.1, but naive mice do not; in contrast, TCR CDR3-beta rearrangements of Vbeta18-Jbeta1.2 and Vbeta19-Jbeta1.2 consistently are associated with the spontaneous response," researchers in Rome, Italy report.

"T cells involved...

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