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HIV/AIDS Vaccines
Data on HIV/AIDS vaccines reported by researchers at University of Cape Town, Institute of Infectious Disease and Molecular Medicine
June 11th, 2008
Scientists discuss in 'Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles' new findings in HIV/AIDS. "HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused in frame with Gag have not yet been reported," scientists in Cape Town, South Africa report. "We constructed a range of gag-derived genes encoding in-frame C-terminal fusions of myristoylation-competent native Pr55Gag and p6-truncated Gag (Pr50Gag) to test the...
Source: Vaccine Weekly (2008-06-11)
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