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Gene Therapy
Research from University of London, Medical Department provides new data on gene therapy
June 11th, 2008
According to recent research published in the journal Gene Therapy, "Bacteria-mediated gene transfer (`bactofection') has emerged as an alternative approach for genetic vaccination and gene therapy. Here, we assessed bactofection of airway epithelial cells in vitro and in vivo using an attenuated Escherichia coli genetically engineered to invade non-phagocytic cells. Invasive E. coli expressing green fluorescent protein (GFP) under the control of a prokaryotic promoter was efficiently taken up into the cytoplasm of cystic fibrosis tracheal epithelial (CFTE29o - ) cells and led to dose-related reporter gene expression." "In vivo experiments showed that following...
Source: Vaccine Weekly (2008-06-11)
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