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Immunization
Study findings from K.M. Quinn et al provide new insights into immunization
June 11th, 2008
According to recent research from Wellington, New Zealand, "CD4(+)CD25(+) natural T regulatory cells (Tregs) have been shown to suppress protective immune responses in several different vaccination models. Since the effect of Tregs on vaccination against tuberculosis (Tb) was unknown, we used a murine model to investigate whether natural Tregs suppress the development of protective immunity following Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccination." "Using a monoclonal antibody against CD25, natural Tregs were inactivated prior to vaccination with BCG. The primary immune response was evaluated after BCG vaccination and the secondary immune response was...
Source: Vaccine Weekly (2008-06-11)
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