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Vaccine Weekly

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Immunization



Study findings on immunization are outlined in reports from L Sacco University



June 11th, 2008

According to recent research from Milan, Italy, "Glucocorticoids (GCs) have many complex quantitative and qualitative immunosuppressive effects which induce cellular immunodeficiency and Increase host susceptibility to various viral, bacterial, fungal and parasitic infections. As cortisol secretion is inadequate in chronic immune/inflammatory conditions, and current therapies have the aim of providing adequate (low) compensatory doses, the timing of GC administration, such as during the nocturnal turning-on phase of tumour necrosis factor (TNF) secretion, can be extremely important."

"The use of the lowest possible GC dose, at night, and for the shortest possible time...


Source: Vaccine Weekly (2008-06-11)

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