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Life Sciences
Studies from National Institutes of Health add new findings in the area of life sciences
June 11th, 2008
According to recent research published in the Journal of Translational Medicine, "Upon Ag-activation cytotoxic T cells (CTLs) produce IFN-gamma GM-CSF and TNF-alpha, which deliver simultaneously pro-apoptotic and pro-inflammatory signals to the surrounding microenvironment. Whether this secretion affects in an autocrine loop the CTLs themselves is unknown." "Here, we compared the transcriptional profile of Ag-activated, Flu-specific CTL stimulated with the FLU MI:58-66 peptide to that of convivial CTLs expanded in vitro in the same culture. PBMCs from 6 HLA-A*0201 expressing donors were expanded for 7 days in culture following Flu MI: 58-66 stimulation in the...
Source: Vaccine Weekly (2008-06-11)
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