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Tuberculosis
Reports on tuberculosis findings from M.G. Chaitra and co-researchers provide new insights
June 18th, 2008
According to recent research from Bangalore, India, "CD8(+) T cells are thought to play an important role in protective immunity against tuberculosis. We report the identification of three peptides derived from Rv1818c, Rv3812 and Rv3018c proteins of Mycobacterium tuberculosis that bound to HLA-A*0201 molecules and their ability to induce in vitro T-cell response in peripheral blood lymphocytes from HLA-A*0201-positive healthy individuals (PPD+) and patients with TB." "The peptide-specific cytotoxic T lymphocytes (CTL) generated were capable of recognizing peptide pulsed targets. Three 9-mer peptides bound with high affinity to HLA-A*0201 and displayed low dissociation...
Source: Vaccine Weekly (2008-06-18)
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