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Vaccine Weekly

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Immunotherapy



Researchers from Purdue University, Department of Chemistry describe findings in immunotherapy



June 18th, 2008

Current study results from the report, 'Low-dose radiation potentiates the therapeutic efficacy of folate receptor-targeted hapten therapy,' have been published. "Human cancers frequently overexpress a high-affinity cell-surface receptor for the vitamin folic acid. Highly immunogenic haptens can be targeted to folate receptor-expressing cell surfaces by administration of folate-hapten conjugates, rendering the decorated tumor cell surfaces more recognizable by the immune system," scientists writing in the International Journal of Radiation, Oncology, Biology, Physics report.

"Treatment of antihapten-immunized mice with folate-hapten constructs results in...


Source: Vaccine Weekly (2008-06-18)

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