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Cancer Vaccines
Scientists at University of Ulm describe research in cancer vaccines
June 18th, 2008
According to recent research published in the journal Transfusion, "Dendritic cells (DCs) generated from leukemic blasts constitute a promising tool in immunotherapy for acute myeloid leukemia patients (AML-DCs), because AML-DCs express human leukocyte antigens and costimulatory molecules such as CD40, CD80, and CD86 at a higher level than leukemic blasts. Potentiation of AML-DC vaccine might become feasible by the addition of adjuvants such as lipopolysaccharides (LPS) or CPG-rich oligodeoxyribonucleotides binding to Toll-like receptors (TLR) and inducing a stronger Type 1 T-cell response." "Study desing and methods: mRNA and protein expression of TLR-2, -4, and...
Source: Vaccine Weekly (2008-06-18)
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