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Malaria
Study data from M.E. Patarroyo and co-authors update knowledge of malaria
June 18th, 2008
"A totally effective anti-malarial vaccine must contain epitopes derived from multiple proteins found in different stages of the particular parasite involved in invasion. It must therefore include sporozoite molecules able to induce protective immunity thereby blocking the parasite's access to hepatic cells; thrombospondin-related anonymous protein (TRAP) is one of them," investigators in Bogota, Colombia report. "Conserved high activity binding peptides (HABPs) attaching themselves to hepatic cells were used in immunisation studies with the highly malaria-susceptible Aotus monkey. However, they had to be modified to render them immunogenic. The changes induced in lead...
Source: Vaccine Weekly (2008-06-18)
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