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Protein Mimetics
Reports on protein mimetics findings from Nanyang Technological University provide new insights
June 18th, 2008
Data detailed in 'Quaternary protein mimetics of gp41 elicit neutralizing antibodies against HIV fusion-active intermediate state' have been presented. According to a study from Singapore, Singapore, "During viral entry, the fusogenic state of human immunodeficiency virus Type 1 (HIV-1) envelope protein gp41 is a quaternary structure consisting of three gp41 glycoproteins, each with two conserved helical domains (N-HR and C-HR). Thus far, the examination of monomeric gp41 peptides as an immunologically focused approach to vaccine design has not been successful." "Here we report an approach using quaternary protein mimetics (called 3alpha mimetics) that are based on the...
Source: Vaccine Weekly (2008-06-18)
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