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Glioblastoma Animal Studies
Research on glioblastoma animal studies described by T. Schneider and colleagues
June 25th, 2008
Current study results from the report, 'Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles,' have been published. "We examined a 'double-punch' approach to overcome the escape of glioblastoma cells to the immune surveillance: increasing the immune systems activation by an active specific immunization (ASI) with Newcastle-Disease-Virus infected tumor cells and blocking the TGF-beta production by delivery of TGF-beta antisense oligonucleotides using polybutyl cyanoacrylate nanoparticles (NPs). Gene delivery was first evaluated using the CMV-beta-gal plasmid as a reporter gene," scientists writing in the Journal of Neuroimmunology...
Source: Vaccine Weekly (2008-06-25)
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