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Immunization
Research from University of Pennsylvania in the area of immunization described
June 25th, 2008
Data detailed in 'Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques' have been presented. "Recent data supports that increased expression of PD-1, a negative regulator of immune function, is associated with T cell exhaustion during chronic viral infection. However, PD-1 expression during acute infection and vaccination has not been studied in great detail in primates," scientists in the United States report. "Here, we examine PD-1 expression on CD3(+) T cells following DNA vaccination or lentiviral infection of macaques. Ex vivo peptide stimulation of PBMC from DNA-vaccinated uninfected macaques...
Source: Vaccine Weekly (2008-06-25)
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