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Cancer Vaccines
New findings in cancer vaccines described by F. Botta and co-researchers
June 25th, 2008
According to a study from Locarno, Switzerland, "The aim of the present study was to evaluate the role of beta 2-adrenergic receptors (beta 2-ARs) in the outcome of a dendritic cell (DC)-based cancer vaccine in the murine E.G7-ovalbumin (OVA) model. We found that unlike the beta 2-AR, expressed on antigen loaded DCs, beta 2-ARs expressed in the site of DCs inoculation may influence the efficacy of the antitumor response." "Intradermal injection of Staphylococcus aureus peptidoglycan along with the beta 2-AR-specific antagonist ICI 118,551 increased the local innate cytokine response in tumor-bearing mice. When the adoptive transfer of immature DCs loaded with OVA...
Source: Vaccine Weekly (2008-06-25)
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