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DNA Vaccines
Research on DNA vaccines described by Y. Chen and colleagues
June 25th, 2008
According to recent research published in the journal Science in China Series C - Life Sciences, "Lactate dehydrogenase C4 (LDHC4) is a key enzyme for sperm metabolism. It is distributed specifically in testis and is highly immunogenic." "In this study, two DNA vaccines pVAX1-hLDHC and pVAX1-mLDHC were constructed by inserting coding sequences of human and mice LDHC4 into the eukaryotic expression vector pVAX1. The production of LDHC4 specific antibodies was induced in the sera of vaccinated mice and the reproductive tract secretions of vaccinated female mice through immunization by mucosal surface instillation. Furthermore, the antibody titer increased with the...
Source: Vaccine Weekly (2008-06-25)
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