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Cancer Vaccines
Research from A.K. Simon and colleagues has provided new data on cancer vaccines
June 25th, 2008
According to recent research from Oxford, the United Kingdom, "Carbohydrate antigens such as glycolipids and glycoproteins are over-expressed in a variety of cancers and have therefore been identified as ideal candidates for tumour vaccines. Detection of anti-carbohydrate antibodies is associated with a good prognosis in cancer patients." "However, generation of an efficient adaptive immune response has been hampered by the low immunogenicity of carbohydrates due to tolerance. Here, we describe a method by which tumour-rejecting antibodies directed against carbohydrates can be elicited in two different melanoma mouse models. Thus, using the murine melanoma B16F10...
Source: Vaccine Weekly (2008-06-25)
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