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Immunization
Data on immunization published by researchers at Technical University
June 25th, 2008
"Tumor protein D52 (TPD52) is involved in transformation and metastasis and has been shown to be over-expressed in tumor cells compared to normal cells and tissues. Murine TPD52 (mD52) shares 86% protein identity with the human TPD52 orthologue (hD52)," scientists in the United States report. "To study TPD52 protein as a target for active vaccination recombinant, mD52 was administered as a protein-based vaccine. Naive mice were immunized with either mD52 protein and CpG/ODN as a molecular adjuvant or CpG/ODN alone. Two weeks following the final immunization, mice were challenged s.c. with syngeneic tumor cells that over-express mD52. Two distinct murine tumor cell lines...
Source: Vaccine Weekly (2008-06-25)
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