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Vaccine Weekly

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Melanoma



New findings from P.M. Schiltz and co-authors in the area of melanoma published



June 25th, 2008

"Serum levels of S100B and/or lactate dehydrogenase (LDH) are putative tumor markers in melanoma. Early changes in such markers may correlate with a positive immune response to vaccine therapy," investigators in the United States report.

"In patients with metastatic melanoma, S100B and LDH serum levels were measured at baseline, and 1 week after 3 weekly subcutaneous injections of investigational, patient-specific vaccines consisting of autologous dendritic cells loaded with antigens from irradiated proliferating autologous tumor cells, and suspended in granulocyte macrophage colony-stimulating factor. There was a poor correlation between S100B and LDH levels at...


Source: Vaccine Weekly (2008-06-25)

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