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Vaccine Weekly

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Vaccines



Reports from K. Deng and colleagues advance knowledge in vaccines



June 25th, 2008

According to a study from the United States, "QS-7-Api is an exceedingly potent immuno-adjuvant isolated from the bark of Quillaja saponaria. It is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccine clinical trials."

"Tedious isolation/purification protocols and uncertainty in its structural constitution have hindered the clinical development of QS-7. A chemical Synthesis of QS-7-Api is described, providing structural verification of the adjuvant," wrote K. Deng and colleagues.

The researchers concluded: "A novel semisynthetic sequence to QS-7-Api has also been...


Source: Vaccine Weekly (2008-06-25)

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