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Vaccine Weekly

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DNA Vaccines



Research from D.N. Nguyen et al has provided new information about DNA vaccines



July 2nd, 2008

Current study results from the report, 'Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine),' have been published. According to a study from the United States, "Poly(orthoester) (POE) microspheres have been previously shown to possess certain advantages for the in vivo delivery of DNA vaccines. In particular, timing of DNA release from POE microspheres in response to acidic phagosomal pH was shown to be an important factor in determining immunogenicity, which was hypothesized to be linked to the natural progression of antigen-presenting cell uptake, transfection, maturation, and antigen presentation."

"Here we report...


Source: Vaccine Weekly (2008-07-02)

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