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Immunization
Scientists at University of Nijmegen, Nijmegen Center for Molecular Life Science detail research in immunization
July 2nd, 2008
Fresh data on immunization are presented in the report 'No advantage of cell-penetrating peptides over receptor-specific antibodies in targeting antigen to human dendritic cells for cross-presentation.' According to a study from Nijmegen, Netherlands, "Induction of CTL responses by dendritic cell (DC)-based vaccines requires efficient DC-loading strategies for class I Ags. Coupling Ags to cell-penetrating peptides (CPPs) or receptor-specific Abs improves Ag loading of DCs." "In contrast to CPPs, receptor-specific Abs deliver conjugated Ags to DCs with high specificity, which is advantageous for in vivo strategies. It has, however, been speculated that CPPs facilitate...
Source: Vaccine Weekly (2008-07-02)
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