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Vaccines
Data on vaccines reported by investigators at Center for Biologics Evaluation and Research, Division of Viral Products
July 2nd, 2008
Fresh data on vaccines are presented in the report 'Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc.' "All vaccines and other biological products contain contaminating residual DNA derived from the production cell substrate. Whether this residual cell-substrate DNA can induce tumors in vaccine recipients and thus represent a risk factor has been debated for over 50 years without resolution," researchers in the United States report. "As a first step in resolving this issue, we have generated expression plasmids for the activated human H-ras oncogene and for the murine c-myc proto-oncogene. Their oncogenic activity was...
Source: Vaccine Weekly (2008-07-02)
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