Published in Vaccine Weekly, July 2nd, 2008
"Here, we show that IL-15 codelivered with vaccines can overcome CD4(+) T cell deficiency for promoting longevity of antigen-specific CD8(+) T cells and avoidance of TRAIL-mediated apoptosis. In both priming and secondary responses, IL-15 down-regulates proapoptotic Bax, an intermediate in TRAIL-mediated apoptosis, and...
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