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Apoptosis
Studies from National Institutes of Health have provided new data on apoptosis
July 2nd, 2008
"CD4(+) helper T cells contribute to the induction and maintenance of antigen-specific CD8(+) T cells. Their absence results in short-lived antigen-specific CD8(+) T cells and defective secondary CD8(+) T cell responses because of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis," scientists in the United States report. "Here, we show that IL-15 codelivered with vaccines can overcome CD4(+) T cell deficiency for promoting longevity of antigen-specific CD8(+) T cells and avoidance of TRAIL-mediated apoptosis. In both priming and secondary responses, IL-15 down-regulates proapoptotic Bax, an intermediate in TRAIL-mediated apoptosis, and...
Source: Vaccine Weekly (2008-07-02)
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