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Bacillus Calmette-Guerin Vaccines
New findings from L.H. Ly and co-authors in the area of Bacillus calmette-guerin vaccines published
July 2nd, 2008
According to recent research from the United States, "The cytokine mRNA profiles of primary (arising from inhaled bacilli) and secondary (arising from hematogenous reseeding of the lung) granulomas from the lung lobes of bacillus Calmette-Guerin (BCG)vaccinated and unimmunized guinea pigs challenged with virulent Mycobacterium tuberculosis by the pulmonary route were assessed in situ using laser capture microdissection (LCM) at 6 weeks after infection. The challenge dose chosen was so low that some lung lobes did not receive an implant from the airway." "In unimmunized guinea pigs, some lobes contained either large, necrotic primary lesions or small, non-necrotic...
Source: Vaccine Weekly (2008-07-02)
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