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Life Sciences
Research results from University of Zurich update knowledge of life sciences
July 2nd, 2008
"A current paradigm in immunology is that the strength of T cell responses is governed by antigen dose, localization, and costimulatory signals. This study investigates the influence of antigen kinetics on CD8T cell responses in mice," scientists in Zurich, Switzerland report. "A fixed cumulative antigen dose was administered by different schedules to produce distinct dose-kinetics. Antigenic stimulation increasing exponentially over days was a stronger stimulus for CD8 T cells and antiviral immunity than a single dose or multiple dosing with daily equal doses. The same was observed for dendritic cell vaccination, with regard to T cell and anti-tumor responses, and for...
Source: Vaccine Weekly (2008-07-02)
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