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Simian Immunodeficiency Virus
Data on simian immunodeficiency virus detailed by K. Mansfield and co-authors
July 2nd, 2008
According to a study from the United States, "An attenuated derivative of simian immunodeficiency virus strain 239 deleted of V1-V2 sequences in the envelope gene (SIV239 Delta V1-V2) was used for vaccine/challenge experiments in rhesus monkeys. Peak levels of viral RNA in plasma of 10(4) to 10(6.5) copies/ml in the weeks immediately following inoculation of SIV239 Delta V1-V2 were 10- to 1,000-fold lower than those observed with parental SIV239 (similar to 10(7.3) copies/ml)." "Viral loads consistently remained below 200 copies/ml after 8 weeks of infection by the attenuated SIV239 Delta V1-V2 strain. Viral localization experiments revealed large numbers of infected...
Source: Vaccine Weekly (2008-07-02)
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