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Falciparum Malaria
Findings from Crucell Holland BV advance knowledge in falciparum malaria
July 2nd, 2008
According to recent research from Netherlands, "Prime-boost vaccination regimens with heterologous antigen delivery systems have indicated that redirection of the immune response is feasible. We showed earlier that T-cell responses to circumsporozoite (CS) protein improved significantly when the protein is primed with recombinant adenovirus serotype 35 coding for CS (rAd35.CS)." "The current study was designed to answer the question whether such an effect can be extended to liver-stage antigens (LSA) of Plasmodium falciparum such as LSA-1. Studies with mice have demonstrated that the LSA-1 protein induces strong antibody response but a weak T-cell immunity. We first...
Source: Vaccine Weekly (2008-07-02)
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