Published in Vaccine Weekly, July 9th, 2008
Expression of the CHD5 gene is frequently down-regulated in neuroblastomas, and patients whose tumors lacked CHD5 expression were more likely to have shorter event-free and overall survival compared with patients whose tumors expressed CHD5.
Neuroblastoma tumors often lack one copy of a region on the short arm of chromosome 1, called 1p36.31. Garrett Brodeur, M.D., of the Children's Hospital of Philadelphia and colleagues previously identified the smallest region spanned by the deletion in more than 1,200 patient tumors and found that 23 genes were located...
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