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Vaccine Weekly

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Cholera



Recent findings from University of Gothenburg, Sahlgrenska Academy highlight research in cholera



July 9th, 2008

"The present study was carried out to test the immunostimulatory and adjuvant effects of the non-toxic B subunit of cholera toxin (CTB), CpG oligodeoxynucleotide (ODN) and CpG ODN linked to CTB (CTB-CpG) for generation of immunity against H. pylori in mice. Herein, we showed that CTB-CpG induces more potent proinflammatory cytokine and chemokine responses in the cervical and the mesenteric lymph nodes (CLN and MLN, respectively) cells in vitro compared with those of CTB and CpG ODN," researchers in Gothenburg, Sweden report.

"The adjuvant effects of these agents were examined following intranasal immunization of C57Bl/6 mice with H. pylori lysate in combination with CpG...


Source: Vaccine Weekly (2008-07-09)

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