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Immunization
Studies from West Virginia University, Medical Department provide new data on immunization
July 9th, 2008
According to recent research published in the journal Human Reproduction, "Contraceptive vaccines can provide valuable alternatives to current methods of contraception. We describe here the development of sperm-reactive human single chain variable fragment (scFv) antibodies of defined sperm specificity for immunocontraception." "Peripheral blood leukocytes (PBL) from antisperm antibody-positive immunoinfertile and vasectomized men were activated with human sperm antigens in vitro, and the complementary DNA prepared and PCR-amplified using primers based on all the variable regions of heavy and light chains of immunoglobulins. The scFv repertoire was cloned into...
Source: Vaccine Weekly (2008-07-09)
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