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Cancer Vaccines
Research findings from University of Texas update understanding of cancer vaccines
July 16th, 2008
"Antibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) can be induced when GM-CSF is used as an adjuvant to solid tumor vaccination. Neutralizing anti-GM-CSF IgG has been associated with pulmonary alveolar proteinosis ( PAP), and secondary PAP has been linked to myeloid leukemia," researchers in the United States report. "We studied 69 patients with acute myeloid leukemia, chronic myeloid leukemia and myelodysplastic syndrome, including 19 patients who received GM-CSF with peptide antigen and incomplete Freund's adjuvant in a vaccine trial for the presence or induction of anti-GM-CSF antibodies. Anti-GM-CSF IgG were present in 36 (52%) patients with...
Source: Vaccine Weekly (2008-07-16)
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