Vaccinia Virus

New vaccinia virus study findings reported from University of Michigan

Published in Vaccine Weekly, July 16th, 2008

"Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response. Although vaccinia virus (VV) is known to induce a strong immune response, the effect of VV infection on hematopoiesis remains largely unknown," investigators in the United States report.

"Here, we showed that in vivo VV infection results in the expansion of c-Kit(hi)Sca-1(+)Lin(-) (KSL) hematopoietic stem cells. The in vivo expansion of the KSL population requires MyD88 that is a critical adaptor for Toll-like receptor-mediated signaling. Moreover, in BM of VV-infected...

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Source: Vaccine Weekly (2008-07-16)

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