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Vaccines
Study results from University of Colorado in the area of vaccines published
July 16th, 2008
New research, 'Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying,' is the subject of a report. According to recent research published in the Journal of Pharmaceutical Sciences, "Aluminum-salt adjuvants are widely used to increase immunogenicity of recombinant protein vaccines. However, when vaccines formulated with these adjuvants are frozen or lyophilized, losses of efficacy are often reported." "This loss of potency is usually attributed to the aggregation of adjuvant particles during processing. In this study, we examine the aggregation behavior of Alhydrogel, a commercial aluminum hydroxide adjuvant, during freeze-thawing and...
Source: Vaccine Weekly (2008-07-16)
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