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Human Papillomavirus
New human papillomavirus research from National Institutes of Health described
July 16th, 2008
"Pseudovirions of human papillomavirus type 16 (HPV16), the principal etiologic agent in 50% of cervical cancers, were used as a model system to investigate the cell surface interactions involved in the exposure of the broadly cross-neutralizing papillomavirus L2 epitopes. These neutralizing epitopes were exposed only after cell surface binding and a subsequent change in capsid conformation that permitted cleavage by the cellular protease furin at a specific highly conserved site in L2 that is immediately upstream of the cross-neutralizing epitopes," scientists writing in the Journal of Virology report. "Unexpectedly, binding of L2 antibodies led to the release...
Source: Vaccine Weekly (2008-07-16)
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