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Life Sciences
Study data from Yale University, Medical Department provide new insights into life sciences
July 23rd, 2008
"Aluminium adjuvants, typically referred to as 'alum', are the most commonly used adjuvants in human and animal vaccines worldwide, yet the mechanism underlying the stimulation of the immune system by alum remains unknown. Toll-like receptors are critical in sensing infections and are therefore common targets of various adjuvants used in immunological studies," scientists in the United States report. "Although alum is known to induce the production of proinflammatory cytokines in vitro, it has been repeatedly demonstrated that alum does not require intact Toll-like receptor signalling to activate the immune system(1,2). Here we show that aluminium adjuvants activate an...
Source: Vaccine Weekly (2008-07-23)
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