Malaria Vaccines

Investigators at University of Oxford release new data on malaria vaccines

Published in Vaccine Weekly, July 23rd, 2008

According to recent research published in the American Journal of Tropical Medicine and Hygiene, "There is increasing interest in malaria vaccines targeting the asexual blood stage of Plasmodium falciparum. Without accepted immunologic correlates of clinical protection, challenge studies are useful for assessing the efficacy of candidate vaccines in vivo in healthy volunteers."

"We report a pilot study of a safe and robust challenge protocol using a blood-stage inoculum. We have applied well-validated trial endpoints and twice daily real-time quantitative polymerase chain reaction monitoring of parasitemia to blood-stage challenge, which enabled direct comparison...

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Source: Vaccine Weekly (2008-07-23)

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