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Immunization
Findings from International Vaccine Institute broaden understanding of immunization
July 23rd, 2008
Data detailed in 'OspF directly attenuates the activity of extracellular signal-regulated kinase during invasion by Shigella flexneri in human dendritic cells' have been presented. "Shigella spp., Gram-negative pathogenic bacteria, deliver various effector molecules into the host cell cytoplasm through their type III secretion system to facilitate their invasive process and control the host innate immune responses. Although the function of these effectors is well characterized in epithelial cells during Shigella infection, it has not been elucidated in the dendritic cell (DC), a major antigen presenting cell playing an important role in the initiation of immune responses," scientists in...
Source: Vaccine Weekly (2008-07-23)
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