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Immunization
Researchers at University of Tennessee, Health Science Center have published new data on immunization
July 23rd, 2008
A new study, 'Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3,' is now available. "Alum is the only adjuvant approved for routine use in humans, although the basis for its adjuvanticity remains poorly understood. We have recently shown that alum activates caspase-1 and induces secretion of mature IL-1beta and IL-18," investigators in the United States report. "In this study we show that, in human and mouse macrophages, alum-induced secretion of IL-1beta, IL-18, and IL-33 is mediated by the NLR (nucleotide-binding domain leucine-rich repeat-containing) protein NLRP3 and its adaptor ASC, but not by NLRC4. Other particulate...
Source: Vaccine Weekly (2008-07-23)
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