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Anthrax
Study data from Korea University update knowledge of anthrax
July 23rd, 2008
According to recent research from South Korea, "The generation of protective humoral immune responses against the receptor-binding domain (domain IV) of protective antigen [PA(dIV] of Bacillus anthracis represents a plausible approach against anthrax toxin. In the current study, we have developed a naked DNA vaccine encoding calreticulin (CRT) linked to PA(dIV) of Bacillus anthracis [CRT/PA(dIV)]." "We transfected a human embryonic kidney cell line (HEK 293) with CRT/PA(dIV) DNA and performed Western blotting and confocal microscopy analysis. We found that linkage of CRT to PA(dIV) targets PA(dIV) to the endoplasmic reticulum, resulting in secretion of the chimeric...
Source: Vaccine Weekly (2008-07-23)
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