Published in Vaccine Weekly, July 30th, 2008
"However, the mechanism whereby these long-lived plasma cells are maintained over long periods of time remains an open question. Furthermore, given a finite number of sustainable plasma cells within the bone marrow, it is also unclear how space for newly induced plasma cells is generated without compromising the pre-existing repertoire," wrote J. Wrammert and colleagues, Emory University, Emory Vaccine Center.
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