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Immunization
Study results from D. Herndierbrandstetter et al provide new insights into immunization
July 30th, 2008
According to a study from Innsbruck, Austria, "The age-related decline in immune system functions is responsible for the increased prevalence of infectious diseases and the low efficacy of vaccination in elderly individuals. In particular, the number of peripheral naive T-cells declines throughout life and they exhibit severe functional defects at advanced age." "However, we have recently identified a non-regulatory CD8(+)CD45RO(+) CD25(+) T-cell subset that occurs in a subgroup of healthy elderly individuals, who still exhibit an intact humoral immune response following influenza vaccination. Here, we demonstrate that CD8(+)CD45RO(+)CD25(+) T-cells share phenotypic and...
Source: Vaccine Weekly (2008-07-30)
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