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Chronic Lymphocytic Leukemia Immunology
Data on chronic lymphocytic leukemia immunology reported by researchers at University of Pittsburgh, Pittsburgh Cancer Institute
July 30th, 2008
Fresh data on chronic lymphocytic leukemia are presented in the report 'Type 1-polarized dendritic cells loaded with autologous tumor are a potent immunogen against chronic lymphocytic leukemia.' "Induction of active tumor-specific immunity in patients with chronic lymphocytic leukemia (CLL) and other hematologic malignancies is compromised by the deficit of endogenous dendritic cells (DCs). In attempt to develop improved vaccination strategies for patients with CLL and other tumors with poorly identified rejection antigens, we tested the ability of ex vivo-generated DCs to cross-present the antigens expressed by CLL cells and to induce CLL-specific, functional CTL responses," researchers...
Source: Vaccine Weekly (2008-07-30)
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