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Adenovirus
Reports outline adenovirus study results from Purdue University
July 30th, 2008
According to recent research from the United States, "Because of the high prevalence of adenovirus (Ad) infections in humans, it is believed that pre-existing Adneutralizing antibodies (vector immunity) may negatively impact the immune response to vaccine antigens when delivered by human Ad (HAd) vectors. In order to evaluate whether bovine Ad subtype 3 (BAd3), a non-HAd vector, can effectively elude high levels of pre-existing vector immunity, naive and HAd serotype 5 (HAd)- primed mice were immunized with BAd-H5HA [BAd3 vector expressing the hemagglutinin (HA) gene from H5N1 influenza virus]." "Even in the presence of very high levels of HAd-specific neutralizing...
Source: Vaccine Weekly (2008-07-30)
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