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Encephalomyelitis Vaccines
Research on encephalomyelitis vaccines described by J.M. Kel and colleagues
July 30th, 2008
Fresh data on encephalomyelitis are presented in the report 'Mannosylated self-peptide inhibits the development of experimental autoimmune encephalomyelitis via expansion of nonencephalitogenic T cells.' According to recent research from Leiden, Netherlands, "Tolerance to experimental autoimmune encephalomyelitis (EAE) in SJL mice can be induced by immunization with a mannosylated form of the proteolipid protein (M-PLP139-151), despite the presence of CFA. The state of tolerance is characterized by poor delayed-type hypersensitivity responses and the absence of clinical EAE symptoms." "In vivo monitoring of CFSE-labeled PLP139-151-specific TCR-transgenic (5B6) T cells...
Source: Vaccine Weekly (2008-07-30)
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