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Cytomegalovirus
Data on cytomegalovirus detailed by J. Schalich and co-authors
July 30th, 2008
According to a study from Vienna, Austria, "Human cytomegalovirus (HCMV) is contained by T-lymphocyte responses focused towards the major tegument protein pp65. To systematically identify T-cell epitopes, we applied the following strategy: 441 overlapping 15mer peptides spanning the entire HCMV pp65 antigen in 1-aa steps were screened in enzyme-linked immunospot (ELIspot) assays for interferon gamma (IFN-gamma)secretion by peripheral blood mononuclear cells (PBMCs) from nine healthy HCMV-seropositive subjects expressing human leukocyte antigen (HLA)-A2." "This analysis confirmed a number of previously known epitopes and revealed several new ones. A total of 26 epitopes...
Source: Vaccine Weekly (2008-07-30)
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