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Life Sciences
Study results from R. Grenningloh and colleagues update understanding of life sciences
August 6th, 2008
"Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL)," researchers in Braunschweig, Germany report. "Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes," wrote R....
Source: Vaccine Weekly (2008-08-06)
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