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Myeloma
Study findings from University of Heidelberg broaden understanding of myeloma
August 6th, 2008
"The aim of this study is the identification of HLA-A2 restricted T-cell epitopes in the conserved region of the immunoglobulin-G-heavy-chain (IgG(H)) that can be used for immunotherapy in multiple myeloma (MM) patients. After the IgG(H) gene sequence was scanned for HLA-A2 restricted T-cell epitopes with a high binding affinity to the MHC-I-complex, promising nona-peptides were synthesized," scientists in Heidelberg, Germany report. "Peptide specific CD8 (+) T-cells were generated from peripheral blood mononuclear cells (PBMC) of healthy donors (HD) and patients with MM using peptide pulsed dendritic cells (DC) in vitro. The activation and cytotoxicity of CD8 (+)...
Source: Vaccine Weekly (2008-08-06)
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