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DNA Vaccines
Research from Research Institute for Genetic and Human Therapy reveals new findings on DNA vaccines
August 6th, 2008
Data detailed in 'Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule' have been presented. According to recent research from Pavia, Italy, "DNA vaccines are effective at inducing antigen-specific cellular immune responses. Approaches to improve these responses, however, are needed." "We examined the effect of stimulating 4-1BB, an activation-inducible T-cell costimulatory receptor, by intravenously co-administering anti-human 4-1BB monoclonal antibody (mAb) in DNA-immunized cynomolgus macaques. Three groups of six cynomolgus macaques were immunized intramuscularly with a DNA vaccine encoding SIV Gag antigen (pSIVgag)...
Source: Vaccine Weekly (2008-08-06)
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