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HIV/AIDS
Research results from Torrey Pines Institute for Molecular Studies update understanding of HIV/AIDS
August 6th, 2008
Current study results from the report, 'Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization,' have been published. According to recent research from the United States, "Insights into the process of HIV-1 neutralization may assist rational vaccine design. Here, we compared antibody neutralization against the JR-FL primary isolate and trimer binding affinities judged by native PAGE." "Monovalent Fab-trimer binding and neutralization showed a direct quantitative relationship, implying that neutralization begins as each trimer is occupied by one antibody. At saturation, three Fab or soluble CD4 molecules engaged each trimer. In contrast,...
Source: Vaccine Weekly (2008-08-06)
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