Artificial Chromosomes

Data on artificial chromosomes described by researchers at Virginia Commonwealth University, Medical Department

Published in Vaccine Weekly, August 6th, 2008

"Congenital human cytomegalovirus infections are the major infectious cause of birth defects in the United States. How this virus crosses the placenta and causes fetal disease is poorly understood," scientists writing in the Journal of Virological Methods report.

"Guinea pig cytomegalovirus (GPCMV) is a related virus that provides an important model for studying cytomegaloviral congenital transmission and pathogenesis. In order to facilitate genetic analysis of GPCMV, the 232 kb GPCMV genome was cloned as an infectious bacterial artificial chromosome (BAC). The BAC vector sequences were flanked by LoxP sites to allow efficient excision using Cre recombinase. All...

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Source: Vaccine Weekly (2008-08-06)

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